A dog model for acetaminophen-induced fulminant hepatic failure.

N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure.

We present a 3-month-old female who developed fulminant hepatic failure after ingesting less than 8 mL of clove oil. Initial treatment involved gastrointestinal decontamination, supportive measures, and admission to hospital. She subsequently developed fulminant hepatic failure and was treated with intravenous N-acetylcysteine (N-AC) according to a protocol used for acetaminophen poisoning. Ove...

Administration of hepatic stimulatory substance alone or with other liver growth factors does not ameliorate acetaminophen-induced liver failure.

Sixty-two beagle dogs were given three doses of acetaminophen over a period of 24 hr in a fulminant liver failure model that is 70% lethal in 72 hr. Treatment of the animals with hepatic stimulatory substance alone or in a mixture with insulin, transforming growth factor-alpha and insulin-like growth factor II had no effect on mortality. Evidence of maximum regeneration with a mitotic index 20 ...

Acute fulminant hepatic failure due to colchicine – a rare manifestation of Gloriosa superba poisoning.

Fulminant hepatic failure in childhood

To document the clinical features and complications of fulminant hepatic failure in childhood, 31 consecutive cases (ofwhom only 9 survived) were reviewed. Of 26 children with acute hepatitis (HbSAg-negative), liver function steadily deteriorated in all but 2, and encephalopathy occurred within 3 weeks of the onset of symptoms in all except 3 of them. Eight of these patients survived, as did on...

Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage.

In an analysis of 160 patients with fulminant hepatic failure, the frequency of renal failure in the patiens who had taken an overdose of paracetamol was not significantly higher than in those with hepatic failure due to other causes. The same was found in another group of patients with less severe hepatic damage. In both the latter group and the patients with fulminant hepatic failure, the dev...